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Issue 40, 2011
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Approaches to the synthesis of optically pure helicates

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Abstract

Methods by which helical bimetallic assemblies may be accessed as single isomers are described and reviewed. While there are a number of notable successes, the conclusion is made that no existing approach satisfies the criteria which will allow these fascinating compounds to emerge from the synthetic research laboratory environment to practical application in e.g. healthcare. For this to be achieved the compounds must be optically pure and non-racemising, soluble and chemically stable in water, readily available on a large scale, chemically diverse and synthetically robust.

Graphical abstract: Approaches to the synthesis of optically pure helicates

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Publication details

The article was received on 27 Jul 2011, accepted on 23 Aug 2011 and first published on 15 Sep 2011


Article type: Perspective
DOI: 10.1039/C1DT11423A
Dalton Trans., 2011,40, 10268-10277

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    Approaches to the synthesis of optically pure helicates

    S. E. Howson and P. Scott, Dalton Trans., 2011, 40, 10268
    DOI: 10.1039/C1DT11423A

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