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Issue 12, 2011

New conjugates of β-cyclodextrin with manganese(iii) salophen and porphyrin complexes as antioxidant systems

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Abstract

Oxidative stress is the hallmark of several pathologies like arthritis, hypertension and many neurodegenerative disorders such as Parkinson's and Alzheimer's diseases. In this scenario, antioxidant compounds can play a pivotal role in treating these severe pathologies. The synthesis of molecules able to mimic physiologically-relevant proteins is nowadays of particular interest. Several transition metal complexes, especially manganese(III) complexes with porphyrin and salen-type ligands, have been reported to be superoxide scavengers. Here we report the synthesis and spectroscopic characterization of manganese(III) complexes of 5[4-(6-O-β-cyclodextrin)-phenyl],10,15,20-tri(4-hydroxyphenyl)-porphyrin and of 6A-deoxy-6A[(S-cysteamidobenzoyl(3,4-diamino)-N,N′-bis(salicylidene))]-β-cyclodextrin. The superoxide dismutase activity of the metal complexes was investigated by indirect methods. The catalase and peroxidase activities were tested using ABTS assays.

Graphical abstract: New conjugates of β-cyclodextrin with manganese(iii) salophen and porphyrin complexes as antioxidant systems

Supplementary files

Article information


Submitted
27 Oct 2010
Accepted
14 Jan 2011
First published
14 Feb 2011

Dalton Trans., 2011,40, 2913-2919
Article type
Paper

New conjugates of β-cyclodextrin with manganese(III) salophen and porphyrin complexes as antioxidant systems

V. Oliveri, A. Puglisi and G. Vecchio, Dalton Trans., 2011, 40, 2913 DOI: 10.1039/C0DT01480J

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