Issue 22, 2010
From the journal:

Dalton Transactions

Anticancer activity of opened areneruthenium metalla-assemblies†

Nicolas P. E. Barry,a   Olivier Zava,b   Julien Furrer,c   Paul J. Dysonb  and  Bruno Therrien*a  

* Corresponding authors

a Institute of Chemistry, University of Neuchatel, 51 Ave de Bellevaux, Neuchatel, Switzerland
E-mail: bruno.therrien@unine.ch
Fax: +41 32 7182511

b Institut des Sciences et Ingénierie Chimique, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland

c Service Analytique Facultaire, University of Neuchatel, Case postale 158, Neuchatel, Switzerland

Abstract

Cationic tetranuclear and hexanuclear opened metalla-assemblies incorporating 5,15-bis(4-pyridyl)-10,20-diphenylporphyrin (bpp) or 5,10,15-tris(4-pyridyl)-20-phenylporphyrin (tpp) panels and dinuclear arene ruthenium clips [(p-cymene)2Ru2(OO∩OO)2]2+ (OO∩OO = oxalato, 2,5-dioxydo-1,4-benzoquinonato (dobq)) have been assembled in the presence of silver triflate. All complexes were characterised by NMR, IR and UV-visible spectroscopy and electrospray ionisation mass spectrometry. The cytotoxicities of the tetranuclear and hexanuclear ruthenium complexes have been established on ovarian A2780 and A2780cisR cancer cell lines. The compounds are quite cytotoxic, the most active metalla-assembly being [Ru6(p-cymene)6(dobq)3(tpp)2]6+, with IC50 values of 2.1 μM and 3.8 μM against A2780 and A2780cisR cells, respectively.

Graphical abstract: Anticancer activity of opened arene ruthenium metalla-assemblies

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Article information

DOI
https://doi.org/10.1039/C001521K
Article type
Paper
Submitted
25 Jan 2010
Accepted
13 Apr 2010
First published
04 May 2010

Dalton Trans., 2010,39, 5272-5277

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Anticancer activity of opened arene ruthenium metalla-assemblies

N. P. E. Barry, O. Zava, J. Furrer, P. J. Dyson and B. Therrien, Dalton Trans., 2010, 39, 5272 DOI: 10.1039/C001521K

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