Issue 18, 2010
From the journal:

Dalton Transactions

Porous nanocomposites of PEG-PLA/calcium phosphate: room-temperature synthesis and its application in drug delivery

Qi-Li Tang,ab   Ying-Jie Zhu,*ab   You-Rong Duan,*c   Qi Wang,c   Ke-Wei Wang,a   Shao-Wen Cao,ab   Feng Chena  and  Jin Wuab  

* Corresponding authors

a State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, P. R. China
E-mail: y.j.zhu@mail.sic.ac.cn
Fax: +86-21-52413122
Tel: +86-21-52412616

b Graduate School of Chinese Academy of Sciences, P. R. China

c Shanghai Cancer Institute, Shanghai, P. R. China
E-mail: yrduan@shsci.org

Abstract

We report room-temperature preparation of poly(ethylene glycol)-block-polylactide (PEG-PLA)/calcium phosphate (CP) nanocomposites with a porous morphology. The reaction time and concentration of the inorganic ingredients play an important role in the morphology and chemical composition of the nanocomposite. Thermogravimetry analysis shows that there is approximately 8.5 wt.% of PEG-PLA block copolymer in the nanocomposite. A typical anti-inflammatory drug, ibuprofen, is used to evaluate the drug loading ability and the release behavior of the porous PEG-PLA/CP nanocomposite. The experiments reveal that the nanocomposite has a higher drug loading capacity and favorable drug release property. The drug release kinetics of the porous PEG-PLA/CP nanocomposite is discussed as a three-stage process. The as-prepared porous PEG-PLA/CP nanocomposite is promising for application in drug delivery.

Graphical abstract: Porous nanocomposites of PEG-PLA/calcium phosphate: room-temperature synthesis and its application in drug delivery

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Article information

DOI
https://doi.org/10.1039/B925779A
Article type
Paper
Submitted
08 Dec 2009
Accepted
08 Mar 2010
First published
24 Mar 2010

Dalton Trans., 2010,39, 4435-4439

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Porous nanocomposites of PEG-PLA/calcium phosphate: room-temperature synthesis and its application in drug delivery

Q. Tang, Y. Zhu, Y. Duan, Q. Wang, K. Wang, S. Cao, F. Chen and J. Wu, Dalton Trans., 2010, 39, 4435 DOI: 10.1039/B925779A

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