Issue 48, 2009
From the journal:

Dalton Transactions

A novel ruthenium(iii) complex with a tridentate dianionic P,O,O-ligand showing high cytotoxic activity†

Jimmy A. van Rijn,a   Patricia Marqués-Gallego,a   Jan Reedijk,a   Martin Lutz,b   Anthony L. Spekb  and  Elisabeth Bouwman*a  

* Corresponding authors

a Leiden Institute of Chemistry, Gorlaeus, Laboratories, Leiden University, 2300 Leiden, The Netherlands
E-mail: bouwman@chem.leidenuniv.nl
Fax: (+31) 71527 4451

b Bijvoet Center for Biomolecular Research, Crystal and Structural Chemistry, Utrecht University, Padualaan 8, The Netherlands

Abstract

Tris(o-anisyl)phosphane was reacted with ruthenium(III) chloride forming a novel Ru(III) complex of formula [Ru(PAn3)(P(An)(phenolate)2)Cl] containing a tridentate dianionic P,O,O-ligand and a bidentate neutral P,O ligand. The tridentate ligand was formed by elimination of two methyl groups from the starting ligand in the reaction with the ruthenium salt. The molecular structure was determined by single crystal X-ray diffraction analysis. The compound shows a high cytotoxic activity in ovarian cancer cell lines comparable with cisplatin and overcoming cisplatin-resistance.

Graphical abstract: A novel ruthenium(iii) complex with a tridentate dianionic P,O,O-ligand showing high cytotoxic activity

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Article information

DOI
https://doi.org/10.1039/B909520A
Article type
Paper
Submitted
13 May 2009
Accepted
20 Jul 2009
First published
17 Aug 2009

Dalton Trans., 2009, 10727-10730

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A novel ruthenium(III) complex with a tridentate dianionic P,O,O-ligand showing high cytotoxic activity

J. A. van Rijn, P. Marqués-Gallego, J. Reedijk, M. Lutz, A. L. Spek and E. Bouwman, Dalton Trans., 2009, 10727 DOI: 10.1039/B909520A

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