Issue 8, 2006

New antitumour active platinum compounds containing carboxylate ligands in trans geometry: synthesis, crystal structure and biological activity

Abstract

New asymmetric trans-platinum(II) complexes, composed of an isopropylamine, an azole and two carboxylate leaving groups, are presented. The crystal and molecular structures of one of the complexes has been determined and the cytotoxicity and reactivity with 5′-guanosine monophosphate is reported. The complexes show a reduced reactivity, but no decrease in cytotoxic activity compared to their chloro-counterparts. Furthermore the complexes largely overcome cisplatin resistance, they therefore present an interesting class of antitumour active trans-platinum complexes.

Graphical abstract: New antitumour active platinum compounds containing carboxylate ligands in trans geometry: synthesis, crystal structure and biological activity

Supplementary files

Article information

Article type
Paper
Submitted
31 Aug 2005
Accepted
23 Nov 2005
First published
07 Dec 2005

Dalton Trans., 2006, 1020-1023

New antitumour active platinum compounds containing carboxylate ligands in trans geometry: synthesis, crystal structure and biological activity

S. van Zutphen, E. Pantoja, R. Soriano, C. Soro, D. M. Tooke, A. L. Spek, H. den Dulk, J. Brouwer and J. Reedijk, Dalton Trans., 2006, 1020 DOI: 10.1039/B512357G

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