Issue 3, 2002

Aromatic C–F activation at Ni in the presence of a carbon–chlorine bond: the nickel mediated synthesis of new pyrimidines

Abstract

Treatment of [Ni(COD)2]/PCy3 with 5-chloro-2,4,6-trifluoropyrimidine affords the C–F activation product trans-[NiF(4-C4N2ClF2)(PCy3)2] 2, which reacts with iodine to form 5-chloro-2,6-difluoro-4-iodo-pyrimidine 5.

Graphical abstract: Aromatic C–F activation at Ni in the presence of a carbon–chlorine bond: the nickel mediated synthesis of new pyrimidines

Supplementary files

Article information

Article type
Communication
Submitted
07 Nov 2001
Accepted
14 Dec 2001
First published
07 Jan 2002

J. Chem. Soc., Dalton Trans., 2002, 297-299

Aromatic C–F activation at Ni in the presence of a carbon–chlorine bond: the nickel mediated synthesis of new pyrimidines

M. I. Sladek, T. Braun, B. Neumann and H. Stammler, J. Chem. Soc., Dalton Trans., 2002, 297 DOI: 10.1039/B110128E

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