Issue 1, 2000

Competitive binding of the anticancer drugtitanocene dichloride to N,N ′-ethylenebis(o-hydroxyphenylglycine) and adenosine triphosphate: a model for TiIV uptake and release by transferrin

Abstract

1H and 31P NMR studies show that in aqueous solution the anticancer agent titanocene dichloride (Cp2TiCl2) binds selectively to N,N ′-ethylenebis(o-hydroxyphenylglycine) (H4ehpg) at neutral pH, but preferentially to adenosine triphosphate (ATP) at pH* values below 5.1; intermolecular TiIV transfer from [TiIV(ehpg)(H2O)] to ATP occurs at acidic pH values.

Article information

Article type
Communication
Submitted
03 Nov 1999
Accepted
19 Nov 1999
First published
24 Dec 1999

J. Chem. Soc., Dalton Trans., 2000, 7-9

Competitive binding of the anticancer drug titanocene dichloride to N,N ′-ethylenebis(o-hydroxyphenylglycine) and adenosine triphosphate: a model for TiIV uptake and release by transferrin

M. Guo and P. J. Sadler, J. Chem. Soc., Dalton Trans., 2000, 7 DOI: 10.1039/A908759A

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