Thermodynamic considerations in co-ordination. Part XVII. Glass and chloride electrode studies of carcinostatic ternary and quaternary complexes of nickel and palladium(II) ions with asparaginate and chloride ligands

Abstract

Glass and chloride electrode studies at 25° and I= 3·00M(Na⁺)ClO₄^– have been used to express the equilibria involved in the Ni^II–asparaginate–Cl^––OH^– and Pd^II–asparaginate–Cl^––OH^– systems in terms of formation constants for the following complexes: NiCl⁺, Ni(asn)Cl, Ni(asn)₂Cl^–, Ni(asn)₂ClOH^2– and Pd(asn)H²⁺, Pd(asn)OH, Pd(asn)ClOH^–, Pd(asn)ClH⁺. The relationship between the compositions of these complexes and carcinostatic activity is discussed.