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Issue 5, 2020
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Optimisation of pyruvate hyperpolarisation using SABRE by tuning the active magnetisation transfer catalyst

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Abstract

Hyperpolarisation techniques such as signal amplification by reversible exchange (SABRE) can deliver NMR signals several orders of magnitude larger than those derived under Boltzmann conditions. SABRE is able to catalytically transfer latent magnetisation from para-hydrogen to a substrate in reversible exchange via temporary associations with an iridium complex. SABRE has recently been applied to the hyperpolarisation of pyruvate, a substrate often used in many in vivo MRI studies. In this work, we seek to optimise the pyruvate-13C2 signal gains delivered through SABRE by fine tuning the properties of the active polarisation transfer catalyst. We present a detailed study of the effects of varying the carbene and sulfoxide ligands on the formation and behaviour of the active [Ir(H)22-pyruvate)(sulfoxide)(NHC)] catalyst to produce a rationale for achieving high pyruvate signal gains in a cheap and refreshable manner. This optimisation approach allows us to achieve signal enhancements of 2140 and 2125-fold for the 1-13C and 2-13C sites respectively of sodium pyruvate-1,2-[13C2].

Graphical abstract: Optimisation of pyruvate hyperpolarisation using SABRE by tuning the active magnetisation transfer catalyst

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Supplementary files

Article information


Submitted
18 Oct 2019
Accepted
10 Dec 2019
First published
28 Jan 2020

This article is Open Access

Catal. Sci. Technol., 2020,10, 1343-1355
Article type
Paper

Optimisation of pyruvate hyperpolarisation using SABRE by tuning the active magnetisation transfer catalyst

Ben. J. Tickner, O. Semenova, W. Iali, P. J. Rayner, A. C. Whitwood and S. B. Duckett, Catal. Sci. Technol., 2020, 10, 1343
DOI: 10.1039/C9CY02498K

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