Issue 19, 2019

Recent advances in transition metal-catalysed cross-coupling of (hetero)aryl halides and analogues under ligand-free conditions

Abstract

The formation of new bonds is pivotal in organic chemistry and a prerequisite to life because it allows the construction of complex molecules from simple precursors. This gives credence to the intensive study of metal-catalysed C–C bond formation via cross-coupling reactions over the past few decades. However, despite the tremendous success recorded for ligand-supported palladium in the catalytic transformation of (hetero)aryl halides, the challenges in their practical application lie in their cost and difficulty of preparation, sensitivities to air/moisture, toxicity and complete incompatibility with aqueous media, which remarkably limit their industrial applications. Non-ligated or ligand-free metal-catalysed cross-coupling reactions are attractive alternatives to ligand-supported counterparts due to their recyclability, cost-effectiveness, sustainability and full industrial applications. Over the years, various research groups have strived to advance ligand-free catalytic systems for cross-coupling of (hetero)aryl halides because of the aforementioned advantages. This review highlights the progress, challenges and prospects in ligand-free metal-catalysed cross-coupling of (hetero)aryl halides and their analogues.

Graphical abstract: Recent advances in transition metal-catalysed cross-coupling of (hetero)aryl halides and analogues under ligand-free conditions

Article information

Article type
Minireview
Submitted
11 Jul 2019
Accepted
30 Aug 2019
First published
02 Sep 2019
This article is Open Access
Creative Commons BY license

Catal. Sci. Technol., 2019,9, 5233-5255

Recent advances in transition metal-catalysed cross-coupling of (hetero)aryl halides and analogues under ligand-free conditions

J. I. Ayogu and E. A. Onoabedje, Catal. Sci. Technol., 2019, 9, 5233 DOI: 10.1039/C9CY01331H

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements