Jump to main content
Jump to site search

Issue 15, 2019
Previous Article Next Article

Hydride-catalyzed selectively reductive cleavage of unactivated tertiary amides using hydrosilane

Author affiliations

Abstract

The first hydride-catalyzed reductive cleavage of various unactivated tertiary amides, including the biologically active aryl-phenazine carboxamides and the challenging non-heterocyclic carbonyl functions, using low-cost hydrosilane as a reducing reagent has been developed. The novel catalyst system exhibits high efficiency and exclusive selectivity, providing the desired amines in useful to excellent yields under mild conditions. Overall, this transition metal-free process may offer a versatile alternative to currently employed expensive reducing reagents, high-pressure hydrogen or metal systems for the selective reductive cleavage of amides.

Graphical abstract: Hydride-catalyzed selectively reductive cleavage of unactivated tertiary amides using hydrosilane

Back to tab navigation

Supplementary files

Article information


Submitted
14 May 2019
Accepted
04 Jul 2019
First published
05 Jul 2019

Catal. Sci. Technol., 2019,9, 3874-3878
Article type
Communication

Hydride-catalyzed selectively reductive cleavage of unactivated tertiary amides using hydrosilane

W. Yao, R. Li, J. Yang and F. Hao, Catal. Sci. Technol., 2019, 9, 3874
DOI: 10.1039/C9CY00924H

Social activity

Search articles by author

Spotlight

Advertisements