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Issue 1, 2019
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Asymmetric ring opening of racemic epoxides for enantioselective synthesis of (S)-β-amino alcohols by a cofactor self-sufficient cascade biocatalysis system

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Abstract

A novel one-pot epoxide hydrolase/alcohol dehydrogenase/transaminase cascade process for the asymmetric ring opening of racemic epoxides to enantiopure β-amino alcohols is reported. The product (S)-β-amino alcohols were obtained in 97–99% ee and 79–99% conversion from readily available racemic epoxides.

Graphical abstract: Asymmetric ring opening of racemic epoxides for enantioselective synthesis of (S)-β-amino alcohols by a cofactor self-sufficient cascade biocatalysis system

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Publication details

The article was received on 21 Nov 2018, accepted on 04 Dec 2018 and first published on 04 Dec 2018


Article type: Communication
DOI: 10.1039/C8CY02377H
Citation: Catal. Sci. Technol., 2019,9, 70-74

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    Asymmetric ring opening of racemic epoxides for enantioselective synthesis of (S)-β-amino alcohols by a cofactor self-sufficient cascade biocatalysis system

    J. Zhang, X. Yang, Q. Jia, J. Zhao, L. Gao, W. Gao, H. Chang, W. Wei and J. Xu, Catal. Sci. Technol., 2019, 9, 70
    DOI: 10.1039/C8CY02377H

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