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Issue 9, 2018
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Gold(i)-catalyzed cycloisomerization of ortho-(alkynyl) styrenes: DFT analysis of the crucial role of SbF6 in the elimination of protons

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Abstract

This study reports the first theoretical evidence for the crucial role played by SbF6 in the determination of the regioselectivity in the gold-catalyzed cycloisomerization of ortho-(phenylethynyl) styrenes. According to our calculations, irrespective of using α-substituted or β,β-disubstituted o-(phenylethynyl) styrene, a novel and unusual reaction pathway for elimination of protons involving a four-center-three-electron intermediate, instead of the generation of HSbF6, is observed. On account of the electronic effect, the ring expansion pathway is more favorable than the elimination pathway for α-substituted o-(phenylethynyl) styrene. By using β,β-disubstituted o-(phenylethynyl) styrene, an elimination pathway involving the four-center-three-electron intermediate affords the indenyl derivative. Based on our calculation results and experimental facts, the regioselectivity for the title reaction is mainly controlled by electronic effects rather than steric effects. The theoretical results not only well rationalize the experimental observations but also provide insights into the details of the reaction.

Graphical abstract: Gold(i)-catalyzed cycloisomerization of ortho-(alkynyl) styrenes: DFT analysis of the crucial role of SbF6− in the elimination of protons

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Article information


Submitted
20 Feb 2018
Accepted
29 Mar 2018
First published
02 Apr 2018

Catal. Sci. Technol., 2018,8, 2441-2448
Article type
Paper

Gold(I)-catalyzed cycloisomerization of ortho-(alkynyl) styrenes: DFT analysis of the crucial role of SbF6 in the elimination of protons

R. Fang, L. Zhou, P. Tu and L. Yang, Catal. Sci. Technol., 2018, 8, 2441
DOI: 10.1039/C8CY00367J

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