Issue 9, 2016

One-pot biocatalytic amine transaminase/acyl transferase cascade for aqueous formation of amides from aldehydes or ketones

Abstract

An efficient one-pot one-step biocatalytic amine transaminase/acyl transferase cascade for the formation of amides from the corresponding aldehydes and ketones in aqueous solution has been developed. N-Benzyl-2-methoxyacetamide has been synthesized utilizing the developed cascade with conversions up to 97%. The cascade was also evaluated for the synthesis of chiral amides.

Graphical abstract: One-pot biocatalytic amine transaminase/acyl transferase cascade for aqueous formation of amides from aldehydes or ketones

Supplementary files

Article information

Article type
Communication
Submitted
26 Feb 2016
Accepted
11 Apr 2016
First published
11 Apr 2016
This article is Open Access
Creative Commons BY license

Catal. Sci. Technol., 2016,6, 2897-2900

One-pot biocatalytic amine transaminase/acyl transferase cascade for aqueous formation of amides from aldehydes or ketones

H. Land, P. Hendil-Forssell, M. Martinelle and P. Berglund, Catal. Sci. Technol., 2016, 6, 2897 DOI: 10.1039/C6CY00435K

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