Issue 13, 2016

Cu-catalysed pyrazole synthesis in continuous flow

Abstract

The synthesis of 1,4-disubstituted pyrazoles via the cycloaddition reaction of sydnones and terminal alkynes has been achieved employing silica-supported copper catalysts. Furthermore, this methodology has been successfully implemented in continuous flow conditions using prepacked stainless steel cartridges containing the solid-supported copper promoter. Finally, we demonstrate that this synthetic procedure can be successfully scaled up to produce practically useful amounts of pyrazole products within 2–5 hours.

Graphical abstract: Cu-catalysed pyrazole synthesis in continuous flow

Supplementary files

Article information

Article type
Paper
Submitted
23 Dec 2015
Accepted
06 Feb 2016
First published
08 Feb 2016
This article is Open Access
Creative Commons BY license

Catal. Sci. Technol., 2016,6, 4718-4723

Cu-catalysed pyrazole synthesis in continuous flow

J. Comas-Barceló, D. Blanco-Ania, S. A. M. W. van den Broek, P. J. Nieuwland, J. P. A. Harrity and F. P. J. T. Rutjes, Catal. Sci. Technol., 2016, 6, 4718 DOI: 10.1039/C5CY02247A

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