Issue 3, 2014

Pd/tetraphosphine catalytic system for Cu-free Sonogashira reaction “on water”

Abstract

An efficient copper-free Sonogashira coupling reaction was performed on water at 100 °C with N,N,N′,N′-tetra(diphenylphosphinomethyl)pyridine-2,6-diamine (1) as a ligand, [Pd(η3-C3H5)Cl]2 as a catalyst precursor and K3PO4 as a base. Both aryl and heteroaryl halides were successfully alkynylated in this system, and a high turnover number (TON) up to 860 000 was obtained with a catalyst loading as low as 1 ppm.

Graphical abstract: Pd/tetraphosphine catalytic system for Cu-free Sonogashira reaction “on water”

Supplementary files

Article information

Article type
Paper
Submitted
22 Oct 2013
Accepted
20 Nov 2013
First published
22 Nov 2013

Catal. Sci. Technol., 2014,4, 746-751

Pd/tetraphosphine catalytic system for Cu-free Sonogashira reaction “on water”

R. Zhou, W. Wang, Z. Jiang, H. Fu, X. Zheng, C. Zhang, H. Chen and R. Li, Catal. Sci. Technol., 2014, 4, 746 DOI: 10.1039/C3CY00831B

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