Application of magnetic nanoparticle-supported CuBr: a highly efficient and reusable catalyst for the one-pot and scale-up synthesis of 1,2,3-triazoles under microwave-assisted conditions

Abstract

An efficient and practical approach was developed to synthesize 1,2,3-triazoles using recyclable Fe₃O₄ magnetic nanoparticle (MNP)-supported copper(I) catalysts via a one-pot multi-component copper-catalyzed azide–alkyne cycloaddition (CuAAC) reaction in water. Under microwave irradiation conditions, terminal alkynes reacted quickly with benzyl/alkyl azides, which were generated in situ from corresponding primary halides and sodium azide. The 1,2,3-triazoles can be exclusively generated in good to excellent yields and on a multi-gram scale.