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Issue 6, 2013
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Substrate promiscuity of cytochrome P450 RhF

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Cytochrome P450 RhF displays a high degree of substrate promiscuity, mediating a range of O-dealkylations, aromatic hydroxylations, epoxidations and asymmetric sulfoxidations. The self-sufficient nature of this CYP coupled with its ability to catalyse the oxidation of a wide range of functional groups highlights this enzyme as an excellent starting template for directed evolution and promising alternate to P450 BM3.

Graphical abstract: Substrate promiscuity of cytochrome P450 RhF

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The article was received on 05 Feb 2013, accepted on 29 Mar 2013 and first published on 03 Apr 2013

Article type: Communication
DOI: 10.1039/C3CY00091E
Catal. Sci. Technol., 2013,3, 1490-1492

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    Substrate promiscuity of cytochrome P450 RhF

    E. O'Reilly, M. Corbett, S. Hussain, P. P. Kelly, D. Richardson, S. L. Flitsch and N. J. Turner, Catal. Sci. Technol., 2013, 3, 1490
    DOI: 10.1039/C3CY00091E

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