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Issue 10, 2012
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Development of the BIPI ligands for asymmetric hydrogenation

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Abstract

The detailed development of unique BIPI ligands suitable for asymmetric hydrogenation is described, and the process research leading to their kilogram-scale manufacture is discussed. Full optimization of each ligand region is shown, and the complete design features for these ligands are explained. Application of the best members of this ligand class to asymmetric hydrogenations of ureaesters, BOC- and CBZ-enecarbamates, and a variety of enamides are described. A novel resolution of P-chiral ligand precursors via their zinc complexes is described, and the research leading to the discovery of catalysts capable of carrying out asymmetric hydrogenations in >99% ee at multi-kilogram scale are presented.

Graphical abstract: Development of the BIPI ligands for asymmetric hydrogenation

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Publication details

The article was received on 21 May 2012, accepted on 03 Jul 2012 and first published on 04 Jul 2012


Article type: Paper
DOI: 10.1039/C2CY20337E
Catal. Sci. Technol., 2012,2, 2083-2089

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    Development of the BIPI ligands for asymmetric hydrogenation

    C. A. Busacca, J. C. Lorenz, A. K. Saha, S. Cheekoori, N. Haddad, D. Reeves, H. Lee, Z. Li, S. Rodriguez and C. H. Senanayake, Catal. Sci. Technol., 2012, 2, 2083
    DOI: 10.1039/C2CY20337E

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