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Issue 1, 2012
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Silicananoparticles efficiently catalyzed synthesis of quinolines and quinoxalines

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Abstract

In this work, highly efficient, green and inexpensive procedures for the preparation of quinoxaline and quinoline derivatives as attractive aza-polycyclic compounds are described. Silica nanoparticles-catalyzed condensation of 1,2-diamines with 1,2-diketones under solvent-free conditions at room temperature affords high yields of quinoxalines with short reaction times. Moreover, the microwave-assisted Friedländer hetero-annulation reaction between 2-aminoaryl ketones and carbonyl compounds in the presence of silica nanoparticles (NPs) as catalysts gives high yields of quinoline derivatives with short reaction times. These reactions have been done in neutral conditions. The NPs catalysts can be reused without lost of activity even after recycling fourteen times .

Graphical abstract: Silica nanoparticles efficiently catalyzed synthesis of quinolines and quinoxalines

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Publication details

The article was received on 20 Aug 2011, accepted on 17 Sep 2011 and first published on 27 Oct 2011


Article type: Paper
DOI: 10.1039/C1CY00332A
Catal. Sci. Technol., 2012,2, 201-214

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    Silica nanoparticles efficiently catalyzed synthesis of quinolines and quinoxalines

    A. Hasaninejad, M. Shekouhy and A. Zare, Catal. Sci. Technol., 2012, 2, 201
    DOI: 10.1039/C1CY00332A

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