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Issue 17, 2020
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Microfluidic lumen-based systems for advancing tubular organ modeling

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Abstract

Microfluidic lumen-based systems are microscale models that recapitulate the anatomy and physiology of tubular organs. These technologies can mimic human pathophysiology and predict drug response, having profound implications for drug discovery and development. Herein, we review progress in the development of microfluidic lumen-based models from the 2000s to the present. The core of the review discusses models for mimicking blood vessels, the respiratory tract, the gastrointestinal tract, renal tubules, and liver sinusoids, and their application to modeling organ-specific diseases. We also highlight emerging application areas, such as the lymphatic system, and close the review discussing potential future directions.

Graphical abstract: Microfluidic lumen-based systems for advancing tubular organ modeling

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Article information


Submitted
09 Jun 2020
First published
06 Aug 2020

Chem. Soc. Rev., 2020,49, 6402-6442
Article type
Review Article

Microfluidic lumen-based systems for advancing tubular organ modeling

M. Virumbrales-Muñoz, J. M. Ayuso, M. M. Gong, M. Humayun, M. K. Livingston, K. M. Lugo-Cintrón, P. McMinn, Y. R. Álvarez-García and D. J. Beebe, Chem. Soc. Rev., 2020, 49, 6402
DOI: 10.1039/D0CS00705F

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