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Issue 12, 2020
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Controlled binding of organic guests by stimuli-responsive macrocycles

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Abstract

Synthetic supramolecular chemistry pursues not only the construction of new matter, but also control over its inherently dynamic behaviour. In this context, classic host–guest chemistry, based on the development of a myriad of macrocyclic receptors with fine-tuned affinities and selectivities, has enormously contributed to the discovery of new chemical function under self-assembly conditions. In turn, the use of molecular switches as control units within host–guest assemblies opened the door for the regulation of their dynamic interactional behaviour, which can be translated into controlled aggregation. In this review, we will focus on different strategies developed for the regulated binding of organic molecules by switchable macrocyclic hosts. As we will see, an appropriate design using stimuli-responsive versions of well-known organic receptors allows the molecular switches implemented within their structures to transform their regulated behaviour from the molecular to the supramolecular level.

Graphical abstract: Controlled binding of organic guests by stimuli-responsive macrocycles

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Article information


Submitted
11 Feb 2020
First published
12 May 2020

Chem. Soc. Rev., 2020,49, 3834-3862
Article type
Review Article

Controlled binding of organic guests by stimuli-responsive macrocycles

A. Blanco-Gómez, P. Cortón, L. Barravecchia, I. Neira, E. Pazos, C. Peinador and M. D. García, Chem. Soc. Rev., 2020, 49, 3834 DOI: 10.1039/D0CS00109K

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