Issue 21, 2018

Aryne-based strategy in the total synthesis of naturally occurring polycyclic compounds

Abstract

The total syntheses of polycyclic natural products by exploiting an aryne as the key reactive species are reviewed. A short introduction summarizes the basic reactivities of aryne species as well as the methods for its generation. In the main part, early examples and the recent reports (mainly 2012–present) on the use of arynes in multistep syntheses are described.

Graphical abstract: Aryne-based strategy in the total synthesis of naturally occurring polycyclic compounds

Article information

Article type
Review Article
Submitted
01 May 2018
First published
24 Oct 2018

Chem. Soc. Rev., 2018,47, 8030-8056

Aryne-based strategy in the total synthesis of naturally occurring polycyclic compounds

H. Takikawa, A. Nishii, T. Sakai and K. Suzuki, Chem. Soc. Rev., 2018, 47, 8030 DOI: 10.1039/C8CS00350E

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