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Issue 23, 2017
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Design and chemical synthesis of eukaryotic chromosomes

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Abstract

Following the discovery of the DNA double helix structure and the advancement of genome sequencing, we have entered a promising stage with regard to genome writing. Recently, a milestone breakthrough was achieved in the chemical synthesis of designer yeast chromosomes. Here, we review the systematic approaches to the de novo synthesis of designer eukaryotic chromosomes, with an emphasis on technologies and methodologies that enable design, building, testing and debugging. The achievement of chemically synthesized genomes with customized genetic features offers an opportunity to rebuild genome organization, remold biological functions and promote life evolution, which will be of great benefit for application in medicine and industrial manufacturing.

Graphical abstract: Design and chemical synthesis of eukaryotic chromosomes

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Article information


Submitted
22 Mar 2017
First published
02 Nov 2017

Chem. Soc. Rev., 2017,46, 7191-7207
Article type
Tutorial Review

Design and chemical synthesis of eukaryotic chromosomes

Z. Xie, D. Liu, B. Li, M. Zhao, B. Zeng, Y. Wu, Y. Shen, T. Lin, P. Yang, J. Dai, Y. Cai, H. Yang and Y. Yuan, Chem. Soc. Rev., 2017, 46, 7191
DOI: 10.1039/C7CS00208D

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