Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.

Issue 23, 2017
Previous Article Next Article

Design and chemical synthesis of eukaryotic chromosomes

Author affiliations


Following the discovery of the DNA double helix structure and the advancement of genome sequencing, we have entered a promising stage with regard to genome writing. Recently, a milestone breakthrough was achieved in the chemical synthesis of designer yeast chromosomes. Here, we review the systematic approaches to the de novo synthesis of designer eukaryotic chromosomes, with an emphasis on technologies and methodologies that enable design, building, testing and debugging. The achievement of chemically synthesized genomes with customized genetic features offers an opportunity to rebuild genome organization, remold biological functions and promote life evolution, which will be of great benefit for application in medicine and industrial manufacturing.

Graphical abstract: Design and chemical synthesis of eukaryotic chromosomes

Back to tab navigation

Article information

22 Mar 2017
First published
02 Nov 2017

Chem. Soc. Rev., 2017,46, 7191-7207
Article type
Tutorial Review

Design and chemical synthesis of eukaryotic chromosomes

Z. Xie, D. Liu, B. Li, M. Zhao, B. Zeng, Y. Wu, Y. Shen, T. Lin, P. Yang, J. Dai, Y. Cai, H. Yang and Y. Yuan, Chem. Soc. Rev., 2017, 46, 7191
DOI: 10.1039/C7CS00208D

Social activity

Search articles by author