Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.

Issue 9, 2017
Previous Article Next Article

Crystallography of encapsulated molecules

Author affiliations


The crystallography of supramolecular host–guest complexes is reviewed and discussed as a part of small molecule crystallography. In these complexes, the host binds the guests through weak supramolecular interactions, such as hydrogen and halogen bonding, cation–π, anion–π, C–H–π, π–π, C–H–anion interactions and the hydrophobic effect. As the guest often shows severe disorder, large thermal motion and low occupancies, the reliable crystallographic determination of the guest can be very demanding. The analysis of host–guest interactions using tools such as Hirshfeld and cavity volume surface analysis will help to look closely at the most important host–guest interactions. The jewel in the crown of utilizing host–guest interactions in the solid-state is the recently developed Crystalline Sponge Method (CSM) by Makoto Fujita. This method, when successful, gives an accurate and unambiguous 3-D structure of the structurally unknown guest molecule from only micro- or nanogram amounts of the guest molecule. In the case of an optically pure enantiomer, its absolute configuration can be determined.

Graphical abstract: Crystallography of encapsulated molecules

Back to tab navigation

Article information

03 Feb 2017
First published
05 Apr 2017

Chem. Soc. Rev., 2017,46, 2638-2648
Article type
Review Article

Crystallography of encapsulated molecules

K. Rissanen, Chem. Soc. Rev., 2017, 46, 2638
DOI: 10.1039/C7CS00090A

Social activity

Search articles by author