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Issue 8, 2017
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Current detection technologies for circulating tumor cells

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Abstract

Circulating tumor cells (CTCs) are cancer cells that circulate in the blood stream after being naturally shed from original or metastatic tumors, and can lead to a new fatal metastasis. CTCs have become a hotspot research field during the last decade. Detection of CTCs, as a liquid biopsy of tumors, can be used for early diagnosis of cancers, earlier evaluation of cancer recurrence and chemotherapeutic efficacy, and choice of individual sensitive anti-cancer drugs. Therefore, CTC detection is a crucial tool to fight against cancer. Herein, we classify the currently reported CTC detection technologies, introduce some representative samples for each technology, conclude the advantages and limitations, and give a future perspective including the challenges and opportunities of CTC detection.

Graphical abstract: Current detection technologies for circulating tumor cells

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Publication details

The article was received on 08 Nov 2016 and first published on 10 Apr 2017


Article type: Tutorial Review
DOI: 10.1039/C6CS00803H
Citation: Chem. Soc. Rev., 2017,46, 2038-2056
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    Current detection technologies for circulating tumor cells

    Z. Shen, A. Wu and X. Chen, Chem. Soc. Rev., 2017, 46, 2038
    DOI: 10.1039/C6CS00803H

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