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Issue 4, 2017

Asymmetric cycloaddition reactions catalysed by diarylprolinol silyl ethers

Author affiliations

Abstract

Cycloaddition reactions are among the most important tools for the construction of cyclic compounds in organic synthesis, since these reactions are vital to access natural products and biologically active compounds. Organocatalysis plays an increasingly pivotal role in these reactions, often allowing several stereocenters to be selectively created and integrated in the target molecule. Among the large number of efficient types of organocatalysts available, the diarylprolinol silyl ethers have been established as one of the most frequently used in aminocatalysis allowing for novel activation modes and reaction concepts. In this review, we will focus on the different activation modes made available by the diarylprolinol silyl ether system with the aim of highlighting their applicability in asymmetric cycloadditions for the assembly of complex molecular architectures.

Graphical abstract: Asymmetric cycloaddition reactions catalysed by diarylprolinol silyl ethers

Article information


Submitted
01 Oct 2016
First published
24 Nov 2016

Chem. Soc. Rev., 2017,46, 1080-1102
Article type
Review Article

Asymmetric cycloaddition reactions catalysed by diarylprolinol silyl ethers

L. Klier, F. Tur, P. H. Poulsen and K. A. Jørgensen, Chem. Soc. Rev., 2017, 46, 1080 DOI: 10.1039/C6CS00713A

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