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Issue 15, 2017
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Fluorine-18 labelled building blocks for PET tracer synthesis

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Abstract

Positron emission tomography (PET) is an important driver for present day healthcare. Fluorine-18 is the most widely used radioisotope for PET imaging and a thorough overview of the available radiochemistry methodology is a prerequisite for selection of a synthetic approach for new fluorine-18 labelled PET tracers. These PET tracers can be synthesised either by late-stage radiofluorination, introducing fluorine-18 in the last step of the synthesis, or by a building block approach (also called modular build-up approach), introducing fluorine-18 in a fast and efficient manner in a building block, which is reacted further in one or multiple reaction steps to form the PET tracer. This review presents a comprehensive overview of the synthesis and application of fluorine-18 labelled building blocks since 2010.

Graphical abstract: Fluorine-18 labelled building blocks for PET tracer synthesis

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Article information


Submitted
28 Jun 2016
First published
13 Jun 2017

This article is Open Access

Chem. Soc. Rev., 2017,46, 4709-4773
Article type
Review Article

Fluorine-18 labelled building blocks for PET tracer synthesis

D. van der Born, A. Pees, A. J. Poot, R. V. A. Orru, A. D. Windhorst and D. J. Vugts, Chem. Soc. Rev., 2017, 46, 4709
DOI: 10.1039/C6CS00492J

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