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Issue 11, 2016
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Organizing multivalency in carbohydrate recognition

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Abstract

The interactions of cell surface carbohydrates as well as of soluble glycoconjugates with their receptor proteins rule fundamental processes in cell biology. One of the supramolecular principles underlying and regulating carbohydrate recognition is multivalency. Many multivalent glycoconjugates have therefore been synthesized to study multivalency effects operative in glycobiology. This review is focused on smaller multivalent structures such as glycoclusters emphasizing carbohydrate-centered and heteromultivalent glycoconjugates. We are discussing primary, secondary and tertiary structural aspects including approaches to organize multivalency.

Graphical abstract: Organizing multivalency in carbohydrate recognition

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Article information


Submitted
30 Mar 2016
First published
05 May 2016

This article is Open Access

Chem. Soc. Rev., 2016,45, 3275-3302
Article type
Review Article

Organizing multivalency in carbohydrate recognition

C. Müller, G. Despras and T. K. Lindhorst, Chem. Soc. Rev., 2016, 45, 3275
DOI: 10.1039/C6CS00165C

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