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Issue 6, 2016
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The development of nanostructure assisted isothermal amplification in biosensors

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Abstract

Developing simple and inexpensive methods to ultrasensitively detect biomarkers is important for medical diagnosis, food analysis and environmental security. In recent years, isothermal amplifications with sensitivity, high speed, specificity, accuracy, and automation have been designed based on interdisciplinary approaches among chemistry, biology, and materials science. In this article, we summarize the advances in nanostructure assisted isothermal amplification in the past two decades for the detection of commercial biomarkers, or biomarkers extracted from cultured cells or patient samples. This article has been divided into three parts according to the ratio of target-to-signal probe in the detection strategy, namely, the N : N amplification ratio, the 1 : N amplification ratio, and the 1 : N2 amplification ratio.

Graphical abstract: The development of nanostructure assisted isothermal amplification in biosensors

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Article information


Submitted
31 Oct 2015
First published
27 Jan 2016

Chem. Soc. Rev., 2016,45, 1738-1749
Article type
Review Article
Author version available

The development of nanostructure assisted isothermal amplification in biosensors

R. Duan, X. Lou and F. Xia, Chem. Soc. Rev., 2016, 45, 1738
DOI: 10.1039/C5CS00819K

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