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Issue 7, 2016
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Multiplex in vitro detection using SERS

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The ability to detect multiple disease-related targets from a single biological sample in a quick and reliable manner is of high importance in diagnosing and monitoring disease. The technique known as surface enhanced Raman scattering (SERS) has been developed for the simultaneous detection of multiple targets present in biological samples. Advances in the SERS method have allowed for the sensitive and specific detection of biologically relevant targets, such as DNA and proteins, which could be useful for the detection and control of disease. This review focuses on the strengths of SERS for the detection of target molecules from complex mixtures and the clinical relevance of recent work combining SERS with multiplexed detection of biological targets.

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Article information

18 Aug 2015
First published
21 Dec 2015

Chem. Soc. Rev., 2016,45, 1901-1918
Article type
Review Article

Multiplex in vitro detection using SERS

S. Laing, K. Gracie and K. Faulds, Chem. Soc. Rev., 2016, 45, 1901
DOI: 10.1039/C5CS00644A

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