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Issue 17, 2015
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Catalytic Conia-ene and related reactions

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Abstract

Since its initial inception, the Conia-ene reaction, known as the intramolecular addition of enols to alkynes or alkenes, has experienced a tremendous development and appealing catalytic protocols have emerged. This review fathoms the underlying mechanistic principles rationalizing how substrate design, substrate activation, and the nature of the catalyst work hand in hand for the efficient synthesis of carbocycles and heterocycles at mild reaction conditions. Nowadays, Conia-ene reactions can be found as part of tandem reactions, and the road for asymmetric versions has already been paved. Based on their broad applicability, Conia-ene reactions have turned into a highly appreciated synthetic tool with impressive examples in natural product synthesis reported in recent years.

Graphical abstract: Catalytic Conia-ene and related reactions

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Article information


Submitted
02 Feb 2015
First published
02 Jun 2015

Chem. Soc. Rev., 2015,44, 6059-6093
Article type
Review Article
Author version available

Catalytic Conia-ene and related reactions

D. Hack, M. Blümel, P. Chauhan, A. R. Philipps and D. Enders, Chem. Soc. Rev., 2015, 44, 6059
DOI: 10.1039/C5CS00097A

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