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Issue 17, 2015
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Development of individualized anti-metastasis strategies by engineering nanomedicines

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Abstract

Metastasis is deadly and also tough to treat as it is much more complicated than the primary tumour. Anti-metastasis approaches available so far are far from being optimal. A variety of nanomedicine formulae provide a plethora of opportunities for developing new strategies and means for tackling metastasis. It should be noted that individualized anti-metastatic nanomedicines are different from common anti-cancer nanomedicines as they specifically target different populations of malignant cells. This review briefly introduces the features of the metastatic cascade, and proposes a series of nanomedicine-based anti-metastasis strategies aiming to block each metastatic step. Moreover, we also concisely introduce the advantages of several promising nanoparticle platforms and their potential for constructing state-of-the-art individualized anti-metastatic nanomedicines.

Graphical abstract: Development of individualized anti-metastasis strategies by engineering nanomedicines

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Publication details

The article was received on 22 Dec 2014 and first published on 09 Jun 2015


Article type: Review Article
DOI: 10.1039/C4CS00511B
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Chem. Soc. Rev., 2015,44, 6258-6286

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    Development of individualized anti-metastasis strategies by engineering nanomedicines

    Q. He, S. Guo, Z. Qian and X. Chen, Chem. Soc. Rev., 2015, 44, 6258
    DOI: 10.1039/C4CS00511B

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