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Issue 12, 2014
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Supramolecular photochemistry of drugs in biomolecular environments

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In this tutorial review we illustrate how the interaction of photoactive drugs/potential drugs with proteins or DNA in supramolecular complexes can determine the course of the reactions initiated by the drug absorbed photons, evidencing the mechanistic differences with respect to the solution conditions. We focus on photoprocesses, independent of oxygen, that lead to chemical modification of the biomolecules, with formation of new covalent bonds or cleavage of existing bonds. Representative systems are mainly selected from the literature of the last decade. The photoreactivity of some aryl propionic acids, (fluoro)quinolones, furocoumarins, metal coordination complexes, quinine-like compounds, naphthaleneimides and pyrenyl-peptides with proteins or DNA is discussed. The use of light for biomolecule photomodification, historically relevant to biological photosensitization processes and some forms of photochemotherapy, is nowadays becoming more and more important in the development of innovative methods in nanomedicine and biotechnology.

Graphical abstract: Supramolecular photochemistry of drugs in biomolecular environments

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Article information

07 Nov 2013
First published
24 Jan 2014

Chem. Soc. Rev., 2014,43, 4051-4067
Article type
Tutorial Review
Author version available

Supramolecular photochemistry of drugs in biomolecular environments

S. Monti and I. Manet, Chem. Soc. Rev., 2014, 43, 4051
DOI: 10.1039/C3CS60402K

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