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Issue 5, 2014
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Protein micro- and nano-capsules for biomedical applications

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Abstract

Micro- and nano-scale systems have emerged as important tools for developing clinically useful drug delivery systems. In this tutorial review, we discuss the exploitation of biomacromolecules for this purpose, focusing on proteins, polypeptides, nucleic acids and polysaccharides and mixtures thereof as potential building blocks for novel drug delivery systems. We focus on the mechanisms of formation of micro- and nano-scale protein-based capsules and shells, as well as on the functionalization of such structures for use in targeted delivery of bioactive materials. We summarise existing methods for protein-based capsule synthesis and functionalization and highlight future challenges and opportunities for delivery strategies based on biomacromolecules.

Graphical abstract: Protein micro- and nano-capsules for biomedical applications

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Publication details

The article was received on 22 Oct 2013 and first published on 12 Dec 2013


Article type: Tutorial Review
DOI: 10.1039/C3CS60376H
Chem. Soc. Rev., 2014,43, 1361-1371

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    Protein micro- and nano-capsules for biomedical applications

    U. Shimanovich, G. J. L. Bernardes, T. P. J. Knowles and A. Cavaco-Paulo, Chem. Soc. Rev., 2014, 43, 1361
    DOI: 10.1039/C3CS60376H

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