Jump to main content
Jump to site search

Issue 2, 2014
Previous Article Next Article

Enantioselective methodologies using N-carbamoyl-imines

Author affiliations


Nucleophilic addition to carbon–nitrogen double bonds (imines) represents one of the most common strategies for the synthesis of amine derivatives. In order to circumvent the problem associated with low reactivity of imines in nucleophilic addition, various imines with electron-withdrawing groups at nitrogen have been studied, and many of them were successfully applied in asymmetric methodologies. Especially N-carbamoyl imines were found to be useful in the enantioselective synthesis of various organic compounds, due to their increased reactivity toward nucleophiles as well as limited difficulties connected with the removal of the carbamoyl moiety in target molecules. The aim of this review is to cover enantioselective methods based on N-carbamoyl imines, focusing on synthetically useful protocols.

Graphical abstract: Enantioselective methodologies using N-carbamoyl-imines

Back to tab navigation

Publication details

The article was received on 09 Sep 2013 and first published on 04 Nov 2013

Article type: Review Article
DOI: 10.1039/C3CS60321K
Chem. Soc. Rev., 2014,43, 611-630
  • Open access: Creative Commons BY license
  •   Request permissions

    Enantioselective methodologies using N-carbamoyl-imines

    J. Vesely and R. Rios, Chem. Soc. Rev., 2014, 43, 611
    DOI: 10.1039/C3CS60321K

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author