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Issue 3, 2014
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Double carbometallation of alkynes: an efficient strategy for the construction of polycycles

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Abstract

Cyclization reactions of alkynes, especially the double carbometallation of alkynes, have drawn much interest from organic chemists because of their high efficiency in the construction of polycycles. Utilizing different nucleophiles or catalytic systems, various efficient strategies to access challenging skeletons have been extensively explored in recent years. In this review, achievements in this field are presented in three major parts (the synsyn, antianti, and synanti addition reactions of diynes or two alkyne molecules). Cyclization reactions of diynes initiated by nucleophiles, [2+2+n] cycloaddition, or other processes and reactions, involving two identical or different alkynes are described, which provide facile and reliable approaches to various π systems, medium-sized rings, and even macrocycles.

Graphical abstract: Double carbometallation of alkynes: an efficient strategy for the construction of polycycles

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Article information


Submitted
29 Aug 2013
First published
26 Nov 2013

Chem. Soc. Rev., 2014,43, 834-846
Article type
Tutorial Review

Double carbometallation of alkynes: an efficient strategy for the construction of polycycles

Y. Luo, X. Pan, X. Yu and J. Wu, Chem. Soc. Rev., 2014, 43, 834
DOI: 10.1039/C3CS60313J

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