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Issue 18, 2013
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Mechanochemical preparation of co-crystals

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The preparation of co-crystals via mechanochemistry combines the quest for clean and green processes with the investigation of multicomponent new materials, among the currently most fashionable systems in the crystal engineering field: the physico-chemical properties of the components add, merge or transform when co-crystals are formed, giving rise to potentially improved performance in “old” solid-state chemistry fields, as in the pharmaceutical industry field, where they represent a way to obtain new formulations and to improve the properties (solubility, thermal stability, compressibility, etc.) of both new and existing drugs.

Graphical abstract: Mechanochemical preparation of co-crystals

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Article information

15 Jan 2013
First published
03 Apr 2013

Chem. Soc. Rev., 2013,42, 7638-7648
Article type
Review Article

Mechanochemical preparation of co-crystals

D. Braga, L. Maini and F. Grepioni, Chem. Soc. Rev., 2013, 42, 7638
DOI: 10.1039/C3CS60014A

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