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Issue 10, 2012
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Progress in palladium-based catalytic systems for the sustainable synthesis of annulated heterocycles: a focus on indole backbones

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Abstract

A survey highlighting the most recent palladium catalytic systems produced and their performances for progress in direct synthesis of indole backbones by heterocarbocyclization of reactive substrates is provided. The discussion is developed in relation with the principles of sustainable chemistry concerning atom and mass economy. In this respect, the general convergent character of the syntheses is of particular interest (one-pot, domino, cascade or tandem reactions), and the substrates accessibility and reactivity, together with the final waste production, are also important. This critical review clearly indicates that the development of ligand chemistry, mainly phosphines and carbenes, in the last few decades gave a significant impetus to powerful functionalization of indoles at virtually all positions of this ubiquitous backbone (118 references).

Graphical abstract: Progress in palladium-based catalytic systems for the sustainable synthesis of annulated heterocycles: a focus on indole backbones

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Publication details

The article was received on 21 Dec 2011 and first published on 26 Mar 2012


Article type: Critical Review
DOI: 10.1039/C2CS15350E
Citation: Chem. Soc. Rev., 2012,41, 3929-3968
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    Progress in palladium-based catalytic systems for the sustainable synthesis of annulated heterocycles: a focus on indole backbones

    M. Platon, R. Amardeil, L. Djakovitch and J. Hierso, Chem. Soc. Rev., 2012, 41, 3929
    DOI: 10.1039/C2CS15350E

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