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Issue 12, 2011
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Control of DNA hybridization by photoswitchable molecular glue

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Hybridization of DNA is one of the most intriguing events in molecular recognition and is essential for living matter to inherit life beyond generations. In addition to the function of DNA as genetic material, DNA hybridization is a key to control the function of DNA-based materials in nanoscience. Since the hybridization of two single stranded DNAs is a thermodynamically favorable process, dissociation of the once formed DNA duplex is normally unattainable under isothermal conditions. As the progress of DNA-based nanoscience, methodology to control the DNA hybridization process has become increasingly important. Besides many reports using the chemically modified DNA for the regulation of hybridization, we focused our attention on the use of a small ligand as the molecular glue for the DNA. In 2001, we reported the first designed molecule that strongly and specifically bound to the mismatched base pairs in double stranded DNA. Further studies on the mismatch binding molecules provided us a key discovery of a novel mode of the binding of a mismatch binding ligand that induced the base flipping. With these findings we proposed the concept of molecular glue for DNA for the unidirectional control of DNA hybridization and, eventually photoswitchable molecular glue for DNA, which enabled the bidirectional control of hybridization under photoirradiation. In this tutorial review, we describe in detail how we integrated the mismatch binding ligand into photoswitchable molecular glue for DNA, and the application and perspective in DNA-based nanoscience.

Graphical abstract: Control of DNA hybridization by photoswitchable molecular glue

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Article information

05 Mar 2011
First published
20 Jun 2011

Chem. Soc. Rev., 2011,40, 5718-5729
Article type
Tutorial Review

Control of DNA hybridization by photoswitchable molecular glue

C. Dohno and K. Nakatani, Chem. Soc. Rev., 2011, 40, 5718
DOI: 10.1039/C1CS15062F

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