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Issue 12, 2011
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Fluorescent DNA-based enzyme sensors

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Fluorescent sensors that make use of DNA structures have become widely useful in monitoring enzymatic activities. Early studies focused primarily on enzymes that naturally use DNA or RNA as the substrate. However, recent advances in molecular design have enabled the development of nucleic acid sensors for a wider range of functions, including enzymes that do not normally bind DNA or RNA. Nucleic acid sensors present some potential advantages over classical small-molecule sensors, including water solubility and ease of synthesis. An overview of the multiple strategies under recent development is presented in this critical review, and expected future developments in microarrays, single molecule analysis, and in vivo sensing are discussed (160 references).

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The article was received on 01 Nov 2010 and first published on 02 Feb 2011

Article type: Critical Review
DOI: 10.1039/C0CS00162G
Citation: Chem. Soc. Rev., 2011,40, 5756-5770
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    Fluorescent DNA-based enzyme sensors

    N. Dai and E. T. Kool, Chem. Soc. Rev., 2011, 40, 5756
    DOI: 10.1039/C0CS00162G

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