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Issue 11, 2010
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Direct amination of aryl halides with ammonia

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The traditional homogeneous access to aromatic amine derivatives is a nucleophilic aromatic substitution of the corresponding aryl halides. The halogen atom is usually relatively inert to amination reaction unless it is activated by the presence of electron withdrawing groups. Consequently, there has been particular emphasis over the past decade on the synthesis of metal complexes that are active catalysts for the preparation of aromatic amines. This tutorial review focuses on the use of metal-based complexes for the direct amination of aryl halides with ammonia.

Graphical abstract: Direct amination of aryl halides with ammonia

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The article was received on 22 Apr 2010 and first published on 28 Sep 2010

Article type: Tutorial Review
DOI: 10.1039/C003692G
Citation: Chem. Soc. Rev., 2010,39, 4130-4145
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    Direct amination of aryl halides with ammonia

    Y. Aubin, C. Fischmeister, C. M. Thomas and J. Renaud, Chem. Soc. Rev., 2010, 39, 4130
    DOI: 10.1039/C003692G

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