Jump to main content
Jump to site search

Issue 5, 2010
Previous Article Next Article

The direct catalytic asymmetric aldol reaction

Author affiliations

Abstract

Asymmetric aldol reactions are a powerful method for the construction of carboncarbon bonds in an enantioselective fashion. Historically this reaction has been performed in a stoichiometric fashion to control the various aspects of chemo-, diastereo-, regio- and enantioselectivity, however, a more atom economical approach would unite high selectivity with the use of only a catalytic amount of a chiral promoter. This critical review documents the development of direct catalytic asymmetric aldol methodologies, including organocatalytic and metal-based strategies. New methods have improved the reactivity, selectivity and substrate scope of the direct aldol reaction and enabled the synthesis of complex molecular targets (357 references).

Graphical abstract: The direct catalytic asymmetric aldol reaction

Back to tab navigation

Article information


Submitted
09 Nov 2009
First published
17 Feb 2010

Chem. Soc. Rev., 2010,39, 1600-1632
Article type
Critical Review

The direct catalytic asymmetric aldol reaction

B. M. Trost and C. S. Brindle, Chem. Soc. Rev., 2010, 39, 1600
DOI: 10.1039/B923537J

Social activity

Search articles by author

Spotlight

Advertisements