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Issue 7, 2007
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Multi-component syntheses of heterocycles by transition-metal catalysis

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For a long time multi-component syntheses of heterocycles have undeniably been a domain of classical carbonyl condensation chemistry. However, the advent of transition-metal catalysis not only has fertilized strategies in heterocyclic synthesis by uni- and bimolecular transformations but the past decade has also witnessed a rapid development of transition-metal catalysis in new multi-component reactions (MCR). Expectedly, palladium catalyzed processes have received a dominant position, yet, other transition-metal complexes are catching up implying organometallic elementary steps that reach even further than cross-coupling and carbometallation. Besides domino MCRs that are purely based upon organometallic catalysis the sequential and consecutive combination with condensation, addition and cycloaddition steps opens a vast playground for the invention of new sequences in heterocyclic synthesis. This tutorial review outlines the underlying reaction based principles of transition-metal catalysis in multi-component syntheses of heterocycles, summarizes recent developments of palladium catalyzed MCR, and highlights the more recent contributions to MCR based heterocyclic synthesis by virtue of rhodium, ruthenium, and copper catalysis.

Graphical abstract: Multi-component syntheses of heterocycles by transition-metal catalysis

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Article information

25 Oct 2006
First published
19 Feb 2007

Chem. Soc. Rev., 2007,36, 1095-1108
Article type
Tutorial Review

Multi-component syntheses of heterocycles by transition-metal catalysis

D. M. D'Souza and T. J. J. Müller, Chem. Soc. Rev., 2007, 36, 1095
DOI: 10.1039/B608235C

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