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Issue 2, 2007
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Biologically active, synthetic ion transporters

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Abstract

The compelling chemical goal of modeling protein channel behavior has led to synthetic compounds that are true ion channels. Although they largely lack the selectivity and sophistication of highly evolved proteins, they successfully perform a variety of biological functions. This tutorial review describes these novel structures and their activity in living systems. Different channel structures show antibacterial to anticancer activity when tested against a variety of cell types.

Graphical abstract: Biologically active, synthetic ion transporters

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Article information


Submitted
30 Aug 2006
First published
05 Dec 2006

Chem. Soc. Rev., 2007,36, 378-389
Article type
Tutorial Review

Biologically active, synthetic ion transporters

G. W. Gokel and I. A. Carasel, Chem. Soc. Rev., 2007, 36, 378
DOI: 10.1039/B605910B

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