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Issue 8, 2006
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Thiamine models and perspectives on the mechanism of action of thiamine-dependent enzymes

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Abstract

Thiamine dependent enzymes catalyze ligase and lyase reactions near a carbonyl moiety. Chemical models for these reactions serve as useful tools to substantiate a detailed mechanism of action. This tutorial review covers all such studies performed thus far, emphasizing the role of each part around the active site and the conformation of the cofactor during catalysis.

Graphical abstract: Thiamine models and perspectives on the mechanism of action of thiamine-dependent enzymes

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Publication details

The article was received on 25 Nov 2005 and first published on 10 Feb 2006


Article type: Tutorial Review
DOI: 10.1039/B514511M
Chem. Soc. Rev., 2006,35, 684-692

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    Thiamine models and perspectives on the mechanism of action of thiamine-dependent enzymes

    G. Malandrinos, M. Louloudi and N. Hadjiliadis, Chem. Soc. Rev., 2006, 35, 684
    DOI: 10.1039/B514511M

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