Microdialysis sampling coupled on-line to microseparation techniques

Abstract

Microdialysis sampling is a powerful tool for continuously monitoring the extracellular concentration of compounds in tissues in vivo. In order to fully utilize the high temporal resolution but small sample volume of the microdialysis technique, several approaches to coupling microdialysis sampling on-line to microseparation techniques have been developed. This article will describe the analytical challenges of microdialysis sampling. Direct coupling of the microdialysis system to the analytical system can provide many benefits. The application of on-line microseparation techniques will be reviewed.