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Issue 1, 1997
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Towards a general triple helix mediated DNA recognition scheme


This review describes new perspectives offered by the synthesis of non-natural nucleosides to overcome current limitations and extend the triplex-mediated DNA recognition scheme to any sequence. Alternate strand purine binding, direct pyrimidine recognition, and binding to the whole base-pair are described. The review highlights structural requirements to the design of modified nucleosides, as well as perturbing events such as tautomeric ambiguity and intercalation for the extended heterocyclic bases.

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Article type: Review Article
DOI: 10.1039/CS9972600063
Citation: Chem. Soc. Rev., 1997,26, 63-71

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    Towards a general triple helix mediated DNA recognition scheme

    S. O. Doronina and J. Behr, Chem. Soc. Rev., 1997, 26, 63
    DOI: 10.1039/CS9972600063

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