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Issue 35, 2019
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Brownian dynamics assessment of enhanced diffusion exhibited by ‘fluctuating-dumbbell enzymes’

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Abstract

Recent experiments have reported that diffusion of enzymes can be enhanced in the presence of their substrates. Using a fluctuating dumbbell model of enzymes, it has been argued that such an enhancement can be rationalized by the reduction of the enzyme size and by the suppression of the hydrodynamically coupled conformational fluctuations, induced by binding a substrate or an inhibitor to the enzyme [Nano Lett. 2017, 17, 4415]. Herein, we critically examine these expectations via extensive Brownian dynamics simulations of a similar model. The numerical results show that neither of the two mechanisms can cause an enhancement comparable to that reported experimentally, unless very large, physically counter-intuitive, enzyme deformations are invoked.

Graphical abstract: Brownian dynamics assessment of enhanced diffusion exhibited by ‘fluctuating-dumbbell enzymes’

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Publication details

The article was received on 19 May 2019, accepted on 19 Aug 2019 and first published on 21 Aug 2019


Article type: Communication
DOI: 10.1039/C9CP02842K
Phys. Chem. Chem. Phys., 2019,21, 18811-18815
  • Open access: Creative Commons BY license
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    Brownian dynamics assessment of enhanced diffusion exhibited by ‘fluctuating-dumbbell enzymes’

    S. Kondrat and M. N. Popescu, Phys. Chem. Chem. Phys., 2019, 21, 18811
    DOI: 10.1039/C9CP02842K

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